Small-molecule agonists of mammalian Diaphanous–related (mDia) formins reveal an effective glioblastoma anti-invasion strategy

The extensive invasive capacity of glioblastoma (GBM) makes it resistant to surgery, radiotherapy, and chemotherapy and thus makes it lethal. In vivo, GBM invasion is mediated by Rho GTPases through unidentified downstream effectors. Mammalian Diaphanous (mDia) family formins are Rho-directed effect...

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Udgivet i:Mol Biol Cell
Main Authors: Arden, Jessica D., Lavik, Kari I., Rubinic, Kaitlin A., Chiaia, Nicolas, Khuder, Sadik A., Howard, Marthe J., Nestor-Kalinoski, Andrea L., Alberts, Arthur S., Eisenmann, Kathryn M.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626057/
https://ncbi.nlm.nih.gov/pubmed/26354425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-11-1502
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