TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages

Theileria-infected macrophages display many features of cancer cells such as heightened invasive capacity; however, the tumor-like phenotype is reversible by killing the parasite. Moreover, virulent macrophages can be attenuated by multiple in vitro passages and so provide a powerful model to elucid...

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Vydáno v:Sci Rep
Hlavní autoři: Haidar, Malak, Whitworth, Jessie, Noé, Gaelle, Liu, Wang Qing, Vidal, Michel, Langsley, Gordon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625156/
https://ncbi.nlm.nih.gov/pubmed/26511382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15688
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