Mucosal Immunogenicity of Genetically Modified Lactobacillus acidophilus Expressing an HIV-1 Epitope within the Surface Layer Protein

Surface layer proteins of probiotic lactobacilli are theoretically efficient epitope-displaying scaffolds for oral vaccine delivery due to their high expression levels and surface localization. In this study, we constructed genetically modified Lactobacillus acidophilus strains expressing the membra...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kajikawa, Akinobu, Zhang, Lin, LaVoy, Alora, Bumgardner, Sara, Klaenhammer, Todd R., Dean, Gregg A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624987/
https://ncbi.nlm.nih.gov/pubmed/26509697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141713
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