Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals

Chromosome abnormalities are common in the human population, causing germ cell loss at meiotic prophase I and infertility. The mechanisms driving this loss are unknown, but persistent meiotic DNA damage and asynapsis may be triggers. Here we investigate the contribution of these lesions to oocyte el...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Cloutier, Jeffrey M., Mahadevaiah, Shantha K., ElInati, Elias, Nussenzweig, André, Tóth, Attila, Turner, James M. A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624946/
https://ncbi.nlm.nih.gov/pubmed/26509888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005462
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