Ticagrelor Does Not Inhibit Adenosine Transport at Relevant Concentrations: A Randomized Cross-Over Study in Healthy Subjects In Vivo

BACKGROUND AND PURPOSE: In patients with myocardial infarction, ticagrelor reduces cardiovascular and sepsis-related mortality, and can cause dyspnea. It is suggested that this is caused by adenosine receptor stimulation, because in preclinical studies, ticagrelor blocks the nucleoside transporter a...

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Udgivet i:PLoS One
Main Authors: van den Berg, T. N. A., El Messaoudi, S., Rongen, G. A., van den Broek, P. H. H., Bilos, A., Donders, A. R. T., Gomes, M. E., Riksen, N. P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624811/
https://ncbi.nlm.nih.gov/pubmed/26509673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137560
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