Repeated Aerosolized-Boosting with Gamma-Irradiated Mycobacterium bovis BCG Confers Improved Pulmonary Protection against the Hypervirulent Mycobacterium tuberculosis Strain HN878 in Mice

Mycobacterium bovis bacillus Calmette-Guerin (BCG), the only licensed vaccine, shows limited protection efficacy against pulmonary tuberculosis (TB), particularly hypervirulent Mycobacterium tuberculosis (Mtb) strains, suggesting that a logistical and practical vaccination strategy is urgently requi...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Cha, Seung Bin, Kim, Woo Sik, Kim, Jong-Seok, Kim, Hongmin, Kwon, Kee Woong, Han, Seung Jung, Eum, Seok-Yong, Cho, Sang-Nae, Shin, Sung Jae
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624807/
https://ncbi.nlm.nih.gov/pubmed/26509812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141577
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