Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders

[Image: see text] Cornelia de Lange Syndrome (CdLS) spectrum disorders are characterized by multiple organ system congenital anomalies that result from mutations in genes encoding core cohesin proteins SMC1A, SMC3, and RAD21, or proteins that regulate cohesin function such as NIPBL and HDAC8. HDAC8...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Decroos, Christophe, Christianson, Nicolas H., Gullett, Laura E., Bowman, Christine M., Christianson, Karen E., Deardorff, Matthew A., Christianson, David W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624487/
https://ncbi.nlm.nih.gov/pubmed/26463496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00881
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