Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

Ewing’s sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease. Ewing’s sarcoma cells are acutely hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibition and this is being evaluated in clinical trials, although the mechanism of hy...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gill, Sonja J., Travers, Jon, Pshenichnaya, Irina, Kogera, Fiona A., Barthorpe, Syd, Mironenko, Tatiana, Richardson, Laura, Benes, Cyril H., Stratton, Michael R., McDermott, Ultan, Jackson, Stephen P., Garnett, Mathew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624427/
https://ncbi.nlm.nih.gov/pubmed/26505995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140988
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