Handling Permutation in Sequence Comparison: Genome-Wide Enhancer Prediction in Vertebrates by a Novel Non-Linear Alignment Scoring Principle

Enhancers have been described to evolve by permutation without changing function. This has posed the problem of how to predict enhancer elements that are hidden from alignment-based approaches due to the loss of co-linearity. Alignment-free algorithms have been proposed as one possible solution. How...

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Veröffentlicht in:PLoS One
Hauptverfasser: Dolle, Dirk, Mateo, Juan L., Eichenlaub, Michael P., Sinn, Rebecca, Reinhardt, Robert, Höckendorf, Burkhard, Inoue, Daigo, Centanin, Lazaro, Ettwiller, Laurence, Wittbrodt, Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624239/
https://ncbi.nlm.nih.gov/pubmed/26505748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141487
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