Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential

Autophagy is a conserved homeostatic process active in all human cells and affecting a spectrum of diseases. Here we use a pharmaceutical screen to discover new mechanisms for activation of autophagy. We identify a subset of pharmaceuticals inducing autophagic flux with effects in diverse cellular s...

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Foilsithe in:Nat Commun
Main Authors: Chauhan, Santosh, Ahmed, Zahra, Bradfute, Steven B., Arko-Mensah, John, Mandell, Michael A., Won Choi, Seong, Kimura, Tomonori, Blanchet, Fabien, Waller, Anna, Mudd, Michal H., Jiang, Shanya, Sklar, Larry, Timmins, Graham S., Maphis, Nicole, Bhaskar, Kiran, Piguet, Vincent, Deretic, Vojo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Pub. Group 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624223/
https://ncbi.nlm.nih.gov/pubmed/26503418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9620
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