Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production

BACKGROUND: The ceramide metabolite, sphingosine-1-phosphate (S1P), regulates multiple cellular functions in keratinocytes (KC). We recently discovered that production of a key innate immune element, cathelicidin antimicrobial peptide (CAMP), is stimulated via a NF-κB-dependent mechanism that is act...

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Vydáno v:J Dermatol Sci
Hlavní autoři: Jeong, Se Kyoo, Kim, Young Il, Shin, Kyong-Oh, Kim, Bong-Woo, Lee, Sin Hee, Jeon, Jeong Eun, Kim, Hyun Jong, Lee, Yong-Moon, Mauro, Theodora M., Elias, Peter M., Uchida, Yoshikazu, Park, Kyungho
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624019/
https://ncbi.nlm.nih.gov/pubmed/26113114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2015.06.007
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