Tumor Priming by Apo2L/TRAIL Reduces Interstitial Fluid Pressure and Enhances Efficacy of Liposomal Gemcitabine in a Patient Derived Xenograft Tumor Model

Interstitial fluid pressure (IFP) is elevated in tumors and high IFP, a negative cancer prognosticator, is known to limit the uptake and efficacy of anti-tumor therapeutics. Approaches that alter the tumor microenvironment and enhance uptake of therapeutics are collectively referred to as tumor “pri...

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Détails bibliographiques
Publié dans:J Control Release
Auteurs principaux: Hylander, Bonnie L., Sen, Arindam, Beachy, Sarah H., Pitoniak, Rose, Ullas, Soumya, Gibbs, John F., Qiu, Jingxin, Prey, Joshua D., Fetterly, Gerald J., Repasky, Elizabeth A.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624014/
https://ncbi.nlm.nih.gov/pubmed/26342663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.08.047
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