Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice

The products of the Slc12a1 and Slc12a2 genes, commonly known as Na(+)-dependent K(+)2Cl(−) co-transporters NKCC2 and NKCC1, respectively, are the targets for the diuretic bumetanide. NKCCs are implicated in the regulation of intracellular chloride concentration ([Cl(−)](i)) in pancreatic β-cells, a...

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Detalhes bibliográficos
Publicado no:J Endocrinol
Main Authors: Alshahrani, Saeed, Almutairi, Mohammed Mashari, Kursan, Shams, Dias-Junior, Eduardo, Almiahuob, Mohamed Mahmoud, Aguilar-Bryan, Lydia, Di Fulvio, Mauricio
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623298/
https://ncbi.nlm.nih.gov/pubmed/26400961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-15-0327
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