EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition

There exists a highly tumorigenic subset of esophageal squamous cell carcinoma (ESCC) cells defined by high expression of CD44. A novel therapy targeting these cancer stem-like cells (CSCs) is needed to improve prognosis of ESCC. CSCs of ESCC have a mesenchymal phenotype and epithelial-mesenchymal t...

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Publicat a:Cancer Biol Ther
Autors principals: Sato, Fumiyuki, Kubota, Yoshimasa, Natsuizaka, Mitsuteru, Maehara, Osamu, Hatanaka, Yutaka, Marukawa, Katsuji, Terashita, Katsumi, Suda, Goki, Ohnishi, Shunsuke, Shimizu, Yuichi, Komatsu, Yoshito, Ohashi, Shinya, Kagawa, Shingo, Kinugasa, Hideaki, Whelan, Kelly A, Nakagawa, Hiroshi, Sakamoto, Naoya
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623069/
https://ncbi.nlm.nih.gov/pubmed/25897987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1040959
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