Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats

Background: Liver fibrosis is a complex inflammatory and fibrogenic process, and the progression of fibrosis leads to cirrhosis. The only therapeutic approaches are the removal of injurious stimuli and liver transplantation. Therefore, the development of anti-fibrotic therapies is desired. Palmitoyl...

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Bibliographic Details
Main Authors: Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
palmitoylethanolamide
carbon tetrachloride
liver fibrosis
hepatic stellate cells (HSCs)
transforming growth factor-β
smad
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00709/full
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