A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19(+) tumor cells

To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific CD19/CD3 tandem diabody (TandAb) consisting solely of Fv domains. The molecule exhibits good manufacturability and stability properties. AFM11 h...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Reusch, Uwe, Duell, Johannes, Ellwanger, Kristina, Herbrecht, Carmen, Knackmuss, Stefan HJ, Fucek, Ivica, Eser, Markus, McAleese, Fionnuala, Molkenthin, Vera, Le Gall, Fabrice, Topp, Max, Little, Melvyn, Zhukovsky, Eugene A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622993/
https://ncbi.nlm.nih.gov/pubmed/25875246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1029216
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