A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30(+) tumor cells

To improve recruitment and activation of natural killer (NK) cells to lyse tumor cells, we isolated a human anti-CD16A antibody with similar affinity for the CD16A 158F/V allotypes, but no binding to the CD16B isoform. Using CD16A-targeting Fv domains, we constructed a tetravalent bispecific CD30/CD...

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Hlavní autoři: Reusch, Uwe, Burkhardt, Carmen, Fucek, Ivica, Le Gall, Fabrice, Le Gall, Mikaelle, Hoffmann, Karin, Knackmuss, Stefan HJ, Kiprijanov, Sergej, Little, Melvyn, Zhukovsky, Eugene A
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011917/
https://ncbi.nlm.nih.gov/pubmed/24670809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28591
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