An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3

Polycomblike (Pcl) proteins are important transcriptional regulators and components of the Polycomb Repressive Complex 2 (PRC2). The Tudor domains of human homologs PHF1 and PHF19 have been found to recognize trimethylated lysine 36 of histone H3 (H3K36me3); however, the biological role of Tudor dom...

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Bibliographic Details
Published in:Epigenetics
Main Authors: Gatchalian, Jovylyn, Kingsley, Molly C, Moslet, Stacey D, Rosas Ospina, Ruben D, Kutateladze, Tatiana G
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622940/
https://ncbi.nlm.nih.gov/pubmed/25923537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1042646
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