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Enzalutamide for treatment of CRPC: Rationale for sequencing and potential clinical biomarker for resistance

The androgen receptor (AR) is central to the initiation and progression of prostate cancer, even after castration. There has been some success in therapies targeting AR signaling which have been shown to extend survival in men with castration-resistant prostate cancer (CRPC). Enzalutamide is a poten...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Lochrin, Sarah E, Figg, William D, Finn, Stephen P
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622918/
https://ncbi.nlm.nih.gov/pubmed/25569176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.987575
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