Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma

Pathologic c-Myc expression is frequently detected in human cancers, including Merkel cell carcinoma (MCC), an aggressive skin cancer with no cure for metastatic disease. Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromati...

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Détails bibliographiques
Publié dans:Epigenetics
Auteurs principaux: Sengupta, Deepanwita, Kannan, Aarthi, Kern, Malan, Moreno, Mauricio A, Vural, Emre, Stack, Brendan, Suen, James Y, Tackett, Alan J, Gao, Ling
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Brief Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622756/
https://ncbi.nlm.nih.gov/pubmed/25941994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1034416
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