Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys

QBP359 is an IgG1 human monoclonal antibody that binds with high affinity to human CCL21, a chemokine hypothesized to play a role in inflammatory disease conditions through activation of resident CCR7-expressing fibroblasts/myofibroblasts. The pharmacokinetics (PK) and pharmacodynamics (PD) of QBP35...

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Dettagli Bibliografici
Pubblicato in:MAbs
Autori principali: Dudal, S, Subramanian, K, Flandre, T, Law, WS, Lowe, PJ, Skerjanec, A, Genin, J-C, Duval, M, Piequet, A, Cordier, A, Jarai, G, Van Heeke, G, Taplin, S, Krantz, C, Jones, S, Warren, AP, Brennan, FR, Sims, J, Lloyd, P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622749/
https://ncbi.nlm.nih.gov/pubmed/26230385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1060384
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