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Markedly prolonged incubation period of hepatitis B in a chimpanzee passively immunized with a human monoclonal antibody to the a determinant of hepatitis B surface antigen.

The protective efficacy of a human monoclonal antibody directed against the a determinant of hepatitis B virus (HBV) surface antigen was studied in a chimpanzee. A single high dose of 5 mg/kg (body weight) of monoclonal antibody SDZ OST 577 was intravenously administered to a chimpanzee, followed by...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Ogata, N, Ostberg, L, Ehrlich, P H, Wong, D C, Miller, R H, Purcell, R H
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1993
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46227/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464917/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.7.3014
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