The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma

The unsatisfactory outcomes for osteosarcoma necessitate novel therapeutic strategies. This study evaluated the effect of the telomerase inhibitor imetelstat in pre-clinical models of human osteosarcoma. Because the chaperone molecule HSP90 facilitates the assembly of telomerase protein, the ability...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Biol Ther
Egile Nagusiak: Hu, Yafang, Bobb, Daniel, He, Jianping, Hill, D Ashley, Dome, Jeffrey S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2015
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622625/
https://ncbi.nlm.nih.gov/pubmed/25920748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1040964
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