A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment

RAD51-mediated recombinational repair is elevated in multiple myeloma (MM) and predicts poor prognosis. RAD51 has been targeted to selectively sensitize and/or kill tumor cells. Here, we employed a peptide nucleic acid (PNA) to inhibit RAD51 expression in MM cells. We constructed a PNA complementary...

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Foilsithe in:Cancer Biol Ther
Main Authors: Alagpulinsa, David Abasiwani, Yaccoby, Shmuel, Ayyadevara, Srinivas, Shmookler Reis, Robert Joseph
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2015
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622566/
https://ncbi.nlm.nih.gov/pubmed/25996477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1040951
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