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Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts

Gastric cancer is one of the most virulent malignant diseases and is the second leading cause of cancer mortality in the world. The receptor tyrosine kinase MET is constitutively activated in many gastric cancers and its expression is strictly required for survival of some gastric cancer cells. Targ...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Ji, Fujian, Liu, Xuanwen, Wu, Yuanyu, Fang, Xuedong, Huang, Guomin
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622552/
https://ncbi.nlm.nih.gov/pubmed/26543351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S89410
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