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Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G(2)/M arrest and γ-H2AX foci formation in colorectal cancer
BACKGROUND: Poly (ADP-ribose) polymerase 1 (PARP1) has an important role in homologous recombination repair. The purpose of this study was to investigate the effect of PARP1 inhibitor on oxaliplatin treatment for colorectal cancer (CRC). METHODS: A cell counting kit-8 assay was used to determine the...
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| Publicado no: | Onco Targets Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622093/ https://ncbi.nlm.nih.gov/pubmed/26543375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S89154 |
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