Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope “tags”

Immunization of mice or rats with a "non-self" protein is a commonly used method to obtain monoclonal antibodies, and relies on the immune system's ability to recognize the immunogen as foreign. Immunization of an antigen with 100% identity to the endogenous protein, however, will not...

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Veröffentlicht in:MAbs
Hauptverfasser: Percival-Alwyn, Jennifer L, England, Elizabeth, Kemp, Benjamin, Rapley, Laura, Davis, Nicola HE, McCarthy, Grant R, Majithiya, Jayesh B, Corkill, Dominic J, Welsted, Sarah, Minton, Kevin, Cohen, E Suzanne, Robinson, Matthew J, Dobson, Claire, Wilkinson, Trevor CI, Vaughan, Tristan J, Groves, Maria AT, Tigue, Natalie J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2014
Schlagworte:
Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622073/
https://ncbi.nlm.nih.gov/pubmed/25523454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985489
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