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PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism

PTEN has been studied in several tumor models as a tumor suppressor. In this study, we explored the role of PTEN in the inhibition state of polarized M2 subtype of macrophage in tumor microenvironment (TME) and the underlying mechanisms. To elucidate the potential effect in TME, RAW 264.7 macrophage...

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Detaylı Bibliyografya
Yayımlandı:Cancer Biol Ther
Asıl Yazarlar: Li, Ning, Qin, Junfang, Lan, Lan, Zhang, Hongyao, Liu, Fang, Wu, Zhaozhen, Ni, Hong, Wang, Yue
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622010/
https://ncbi.nlm.nih.gov/pubmed/25756512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2014.1002353
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