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Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation
BACKGROUND AND PURPOSE: Aryl sulfonamide Na(v)1.3 or Na(v)1.7 voltage‐gated sodium (Na(v)) channel inhibitors interact with the Domain 4 voltage sensor domain (D4 VSD). During studies to better understand the structure‐activity relationship of this interaction, an additional mode of channel modulati...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621986/ https://ncbi.nlm.nih.gov/pubmed/26220736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13259 |
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