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A novel multi‐parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood
BACKGROUND AND PURPOSE: The integrin αLβ2 plays central roles in leukocyte adhesion and T cell activation, rendering αLβ2 an attractive therapeutic target. Compounds with different modes of αLβ2 inhibition are in development, currently. Consequently, there is a foreseeable need for bedside assays, w...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621979/ https://ncbi.nlm.nih.gov/pubmed/26224111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13256 |
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