PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21

Protein phosphatase 2A (PP2A) plays an important role in the control of the cell cycle. We previously reported that the PP2A inhibitors, cantharidin and okadaic acid (OA), efficiently repressed the growth of cancer cells. In the present study, we found that PP2A inhibitors arrested the cell cycle at...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gong, Fei-Ran, Wu, Meng-Yao, Shen, Meng, Zhi, Qiaoming, Xu, Ze-Kuan, Wang, Rong, Wang, Wen-Jie, Zong, Yang, Li, Zeng-Liang, Wu, Yadi, Zhou, Binhua P., Chen, Kai, Tao, Min, Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621904/
https://ncbi.nlm.nih.gov/pubmed/26053095
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