A Human Ventricular Myocyte Model with a Refined Representation of Excitation-Contraction Coupling

Cardiac Ca(2+)-induced Ca(2+) release (CICR) occurs by a regenerative activation of ryanodine receptors (RyRs) within each Ca(2+)-releasing unit, triggered by the activation of L-type Ca(2+) channels (LCCs). CICR is then terminated, most probably by depletion of Ca(2+) in the junctional sarcoplasmic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Himeno, Yukiko, Asakura, Keiichi, Cha, Chae Young, Memida, Hiraku, Powell, Trevor, Amano, Akira, Noma, Akinori
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2015
Schlagworte:
Systems Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621846/
https://ncbi.nlm.nih.gov/pubmed/26200878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.017
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