Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells

Luteolin, a flavone, has been shown to exhibit anticancer properties. Here, we investigated whether luteolin affects epithelial–mesenchymal transition (EMT) and invasiveness of pancreatic cancer cell lines and their underlying mechanism. Pancreatic cancer cell lines PANC-1 and SW1990 were used in ou...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Huang, Xince, Dai, Shengjie, Dai, Juji, Xiao, Yuwu, Bai, Yongyu, Chen, Bicheng, Zhou, Mengtao
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621199/
https://ncbi.nlm.nih.gov/pubmed/26527884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S91511
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