Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose–response relationship in murine versus human cell lines and implications for translation into murine models of sepsis

BACKGROUND: Inflammation forms an important part of the human innate immune system and is largely dependent on the activation of the “classical” NF-κB pathway through Toll-like receptors (TLRs). Understanding this has allowed researchers to explore roles of therapeutic targets in managing conditions...

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Detalles Bibliográficos
Publicado en:J Inflamm Res
Autores principales: McCarron, Eamon P, Williams, Dominic P, Antoine, Daniel J, Kipar, Anja, Lemm, Jana, Stehr, Sebastian, Welters, Ingeborg D
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621196/
https://ncbi.nlm.nih.gov/pubmed/26527892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S89097
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