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Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose–response relationship in murine versus human cell lines and implications for translation into murine models of sepsis
BACKGROUND: Inflammation forms an important part of the human innate immune system and is largely dependent on the activation of the “classical” NF-κB pathway through Toll-like receptors (TLRs). Understanding this has allowed researchers to explore roles of therapeutic targets in managing conditions...
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| Publicado no: | J Inflamm Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621196/ https://ncbi.nlm.nih.gov/pubmed/26527892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S89097 |
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