Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liver cirrhosis is a chronic liver disease caused by chronic liver injury, which activates hepatic stellate cells (HSCs) and the secretion of extracellular matrix (ECM). Cirrhosis accounts for an extensive level of morbidity and mortality worldwide, largely due to lack of effective treatment options...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Liu, Jinghua, Li, Jianbo, Fu, Weiwei, Tang, Jiacheng, Feng, Xu, Chen, Jiang, Liang, Yuelong, Jin, Ren’an, Xie, Anyong, Cai, Xiujun
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621191/
https://ncbi.nlm.nih.gov/pubmed/26527860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S92481
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