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Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liver cirrhosis is a chronic liver disease caused by chronic liver injury, which activates hepatic stellate cells (HSCs) and the secretion of extracellular matrix (ECM). Cirrhosis accounts for an extensive level of morbidity and mortality worldwide, largely due to lack of effective treatment options...

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Опубликовано в: :Drug Des Devel Ther
Главные авторы: Liu, Jinghua, Li, Jianbo, Fu, Weiwei, Tang, Jiacheng, Feng, Xu, Chen, Jiang, Liang, Yuelong, Jin, Ren’an, Xie, Anyong, Cai, Xiujun
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621191/
https://ncbi.nlm.nih.gov/pubmed/26527860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S92481
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