Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

Liver cirrhosis is a chronic liver disease caused by chronic liver injury, which activates hepatic stellate cells (HSCs) and the secretion of extracellular matrix (ECM). Cirrhosis accounts for an extensive level of morbidity and mortality worldwide, largely due to lack of effective treatment options...

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Enregistré dans:
Détails bibliographiques
Publié dans:Drug Des Devel Ther
Auteurs principaux: Liu, Jinghua, Li, Jianbo, Fu, Weiwei, Tang, Jiacheng, Feng, Xu, Chen, Jiang, Liang, Yuelong, Jin, Ren’an, Xie, Anyong, Cai, Xiujun
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2015
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621191/
https://ncbi.nlm.nih.gov/pubmed/26527860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S92481
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