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A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency

Gammaherpesviruses (GHVs) carry homologs of cellular genes, including those encoding a viral cyclin that promotes reactivation from latent infection. The viral cyclin has reduced sensitivity to host cyclin-dependent kinase inhibitors in vitro; however, the in vivo significance of this is unclear. He...

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Vydáno v:J Virol
Hlavní autoři: Williams, Lisa M., Niemeyer, Brian F., Franklin, David S., Clambey, Eric T., van Dyk, Linda F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621100/
https://ncbi.nlm.nih.gov/pubmed/26292318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00891-15
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