Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents

The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells exposed to ionizing radiation (IR) or the chemotherapeu...

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Bibliographic Details
Published in:PLoS One
Main Authors: Sabir, Sarah R., Sahota, Navdeep K., Jones, George D. D., Fry, Andrew M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621075/
https://ncbi.nlm.nih.gov/pubmed/26501353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140975
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