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Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation

Chronic hepatitis B virus (HBV) infection affects 240 million people worldwide and is a major risk factor for liver failure and hepatocellular carcinoma. Current antiviral therapy inhibits cytoplasmic HBV genomic replication, but is not curative because it does not directly affect nuclear HBV closed...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tropberger, Philipp, Mercier, Alexandre, Robinson, Margaret, Zhong, Weidong, Ganem, Don E., Holdorf, Meghan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620859/
https://ncbi.nlm.nih.gov/pubmed/26438841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518090112
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