Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15–25% in African children despite effective antimalarial chemotherapy. There are no adjunctive treatments for CM, so there is an urgent need to identify new targets for therapy. Her...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Gordon, Emile B., Hart, Geoffrey T., Tran, Tuan M., Waisberg, Michael, Akkaya, Munir, Kim, Ann S., Hamilton, Sara E., Pena, Mirna, Yazew, Takele, Qi, Chen-Feng, Lee, Chen-Fang, Lo, Ying-Chun, Miller, Louis H., Powell, Jonathan D., Pierce, Susan K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620853/
https://ncbi.nlm.nih.gov/pubmed/26438846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516544112
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