SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML

FLT3 has been identified as a valid target for the treatment of acute myeloid leukemia (AML), and some FLT3 inhibitors have shown very good efficacy in treating AML in clinical trials. Nevertheless, recent studies indicated that relapse and drug resistance are still difficult to avoid, and leukemia...

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Udgivet i:Sci Rep
Main Authors: Ma, Shuang, Yang, Ling-Ling, Niu, Ting, Cheng, Chuan, Zhong, Lei, Zheng, Ming-Wu, Xiong, Yu, Li, Lin-Li, Xiang, Rong, Chen, Li-Juan, Zhou, Qiao, Wei, Yu-Quan, Yang, Sheng-Yong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620497/
https://ncbi.nlm.nih.gov/pubmed/26497577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15646
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