Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.

The predicted human erbB-3 gene product is closely related to epidermal growth factor receptor (EGFR) and erbB-2, which have been implicated as oncogenes in model systems and human neoplasia. We expressed the erbB-3 coding sequence in NIH 3T3 fibroblasts and identified its product as a 180-kDa glyco...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Kraus, M H, Fedi, P, Starks, V, Muraro, R, Aaronson, S A
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1993
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46204/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.7.2900
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