Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress

BACKGROUND: Although some molecularly targeted drugs for colorectal cancer are used clinically and contribute to a better prognosis, the current median survival of advanced colorectal cancer patients is not sufficient. Autophagy, a basic cell survival mechanism mediated by recycling of cellular amin...

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Gepubliceerd in:BMC Cancer
Hoofdauteurs: Sakitani, Kosuke, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Ihara, Sozaburo, Suzuki, Hirobumi, Suzuki, Nobumi, Serizawa, Takako, Kinoshita, Hiroto, Sakamoto, Kei, Nakagawa, Hayato, Tateishi, Keisuke, Maeda, Shin, Ikenoue, Tsuneo, Kawazu, Shoji, Koike, Kazuhiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620020/
https://ncbi.nlm.nih.gov/pubmed/26496833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1789-5
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