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The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2
BACKGROUND: Lafora disease (LD, OMIM 254780) is a fatal neurodegenerative disorder produced mainly by mutations in two genes: EPM2A, encoding the dual specificity phosphatase laforin, and EPM2B, encoding the E3-ubiquitin ligase malin. Although it is known that laforin and malin may form a functional...
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| Publicado no: | BMC Biochem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4619252/ https://ncbi.nlm.nih.gov/pubmed/26493215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-015-0053-6 |
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