A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes

Background: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use of EGFR-targeted therapies. Methods: In this stud...

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Publicado no:Cell Oncol
Main Authors: Heideman, D. A. M., Thunnissen, F. B., Doeleman, M., Kramer, D., Verheul, H. M., Smit, E. F., Postmus, P. E., Meijer, C. J. L. M., Meijer, G.A., Snijders, P. J. F.
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619054/
https://ncbi.nlm.nih.gov/pubmed/19759413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CLO-2009-0489
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