Mitochondrial DNA Depletion Reduces PARP-1 Levels and Promotes Progression of the Neoplastic Phenotype in Prostate Carcinoma

Mitochondrial dysfunction resulting from mitochondrial DNA (mtDNA) mutations and/or depletion has been correlated with cancer progression and drug resistance. To investigate the role of mtDNA in prostate cancer progression, we used LNCaP and PC-3 prostate carcinoma cells as experimental model. Compa...

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Veröffentlicht in:Cell Oncol
Hauptverfasser: Moro, Loredana, Arbini, Arnaldo A., Marra, Ersilia, Greco, Margherita
Format: Artigo
Sprache:Inglês
Veröffentlicht: IOS Press 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618976/
https://ncbi.nlm.nih.gov/pubmed/18607066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CLO-2008-0427
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