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The spliceosome, a potential Achilles heel of MYC-driven tumors

Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a di...

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Bibliographic Details
Published in:Genome Med
Main Authors: Anczuków, Olga, Krainer, Adrian R.
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618744/
https://ncbi.nlm.nih.gov/pubmed/26490253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0234-3
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