Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.
The p53 tumor-suppressor gene encodes a nuclear phosphoprotein that arrests cell cycle progress at G1. It may facilitate DNA damage repair and is frequently mutated in many human tumors. Hodgkin disease, a malignant condition of the lymphoid system, is characterized by the presence of Reed-Sternberg...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46187/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464894/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.7.2817 |
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