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Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.

The p53 tumor-suppressor gene encodes a nuclear phosphoprotein that arrests cell cycle progress at G1. It may facilitate DNA damage repair and is frequently mutated in many human tumors. Hodgkin disease, a malignant condition of the lymphoid system, is characterized by the presence of Reed-Sternberg...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gupta, R K, Patel, K, Bodmer, W F, Bodmer, J G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC46187/
https://ncbi.nlm.nih.gov/pubmed/8464894
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